RIPK2 inhibitor OD36

OD36 is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with KDs of 37 nM.


Cat. No.: EX-A7701	Purity: >98%

	Chemical structure of RIPK2 inhibitor OD36

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	500	In-stock
250mg	1000	In-stock
500mg	1720	In-stock
1g	2800	In-stock
2g	get quote	In-stock
5g	get quote	Inquire

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Synonyms	OD36
CAS No.	1638644-62-8
Purity	>98%
Formula	C16H15ClN4O2
Mol Weight	330.769
Color	White to off-white
State	solid powder
Solubility	DMSO : 33.33 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Justine T Tigno-Aranjuez, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64. [2]. Gonzalo Sánchez-Duffhues, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230.
CoA	CoA of RIPK2 inhibitor OD36


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