RIPK2-IN-5

RIPK2-IN-5 (compound 14) is a high affinity and excellent selectivity RIPK2 inhibitor with an IC50 value of 5.1nM. RIPK2-IN-5 has cellular anti-inflammatory effect and can reduce the secretion of MDP-induced TNF-α with a dose-dependent manner. RIPK2-IN-5 shows moderate stability in human liver microsome. RIPK2-IN-5 can be used for the research of immune diseases.


Cat. No.: EX-A8384	Purity: >98%

	Chemical structure of RIPK2-IN-5

For research only, Do not use for Human!

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CAS No.	2885227-09-6
Purity	>98%
Formula	C21H14N4S
Mol Weight	354.428
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 116.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fan T, et al. Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):282-293.
CoA	CoA of RIPK2-IN-5

Smiles:	N=1C=CC(=CC1)C=2C=CC3=NC=CC(NC=4C=CC=5SC=NC5C4)=C3C2


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