RGN6024

RGN6024 is a brain-penetrant, orally active and reversible small molecule tubulin destabilizer. RGN6024 inhibits microtubule polymerization both in biochemical and cellular assays, binds to the colchicine binding pocket of β-tubulin (SPR: Kd = 6.7 μM; tryptophan assay: Kd = 7.4 μM), and triggers G2/M arrest in glioblastoma (GB) cells. RGN6024 retains activity in βIII-tubulin overexpressing cells. RGN6024 inhibits tumor growth in a GB xenograft mouse model. RGN6024 can be used for the study of glioblastoma (GB) .


Cat. No.: EX-A16291	Purity: >98%

	Chemical structure of RGN6024

For research only, Do not use for Human!

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CAS No.	3055038-20-2
Purity	>98%
Formula	C18H21N5O4S
Mol Weight	403.455
Color	White to off-white
State	Solid
Solubility	soluable in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Patrón LA, et al. RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma. Mol Cancer Ther. 2025 Aug 1;24(8):1129-1144. doi: 10.1158/1535-7163.MCT-24-1208
CoA	CoA of RGN6024

Smiles:	O=C(NC1=NC=C(OC2=CN=C(N=C2)N3CCOCC3)S1)C45CC(OC)(C5)C4


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