RG7112D

RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels .


Cat. No.: EX-A10141	Purity: >98%

	Chemical structure of RG7112D

For research only, Do not use for Human!

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CAS No.	2360561-90-4
Purity	>98%
Formula	C36H42Cl2N4O4
Mol Weight	665.649
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Clare M Adams, et al. Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer. Cancer Discov. 2023 May 4;13(5):1210-1229.
CoA	CoA of RG7112D

Smiles:	C[C@@]1(N(C(=O)N2CCN(CC(O)=O)CC2)C(=N[C@@]1(C)C3=CC=C(Cl)C=C3)C4=C(OCC)C=C(C(C)(C)C)C=C4)C5=CC=C(Cl)C=C5


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