RET-IN-4

RET-IN-4 is a potent, selective and orally active RET inhibitor with IC50s of 1.29 nM, 1.97 nM, and 0.99 nM for RET (WT), RET (V804M), and RET (M918T), respectively. RET-IN-4 exhibits better kinases selectivity against JAK2 (IC50 of 4.4 nM) and FLT3 (IC50 of 30.8 nM). RET-IN-4 has anticancer effects.


Cat. No.: EX-A5125	Purity: >98%

	Chemical structure of RET-IN-4

For research only, Do not use for Human!

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CAS No.	2436473-55-9
Purity	>98%
Formula	C27H31FN10O2
Mol Weight	546.5992
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhibo Luo, et al. Discovery and Optimization of Selective RET Inhibitors via Scaffold Hopping. Bioorg Med Chem Lett. 2021 May 28;128149.
CoA	CoA of RET-IN-4

Smiles:	O=C1N([C@H](C2=CC=C(N3N=CC(F)=C3)N=C2)C)CCOC14CCN(C5=NC(NC6=NNC(C)=C6)=CC(C)=N5)CC4


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