RET-IN-23

RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity.


Cat. No.: EX-A9094	Purity: >98%

	Chemical structure of RET-IN-23

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	980	In-stock
100mg	1550	In-stock
250mg	2100	In-stock
500mg	2850	In-stock

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CAS No.	2479961-46-9
Purity	>98%
Formula	C28H28FN11
Mol Weight	537.594
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. ZhongHui Chen, et al. Heterocyclic compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof. WO2020168939A1.
CoA	CoA of RET-IN-23

Smiles:	CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1


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