RepSox

RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes.


Cat. No.: EX-A2879	Purity: >99%

	Chemical structure of RepSox

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	195	In-stock
1g	385	In-stock
5g	998	In-stock
10g	1880	In-stock
25g	get quote	In-stock

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CAS No.	446859-33-2
Purity	>99%
Formula	C17H13N5
Mol Weight	287.3186
Color	light brown to yellow
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. [2]. Wan-Zhi Tu, et al. RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes. Acta Pharmacol Sin. 2019 Dec;40(12):1523-1531.
CoA	CoA of RepSox

Smiles:	CC1=CC=CC(=N1)C1=C(C=NN1)C1=NC2=C(C=C1)N=CC=C2


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