Raphin1

Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.


Cat. No.: EX-A7558	Purity: >98%

	Chemical structure of Raphin1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	625	In-stock
200mg	885	In-stock
500mg	1285	In-stock
1g	1885	In-stock

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CAS No.	2022961-17-5
Purity	>98%
Formula	C9H12Cl2N4
Mol Weight	247.124
Color	White to off-white
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.
CoA	CoA of Raphin1


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