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Product Information:

R-GSK3685032

(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition.

Cat. No.: EX-A5947    Purity: >98%
Chemical
Chemical structure of R-GSK3685032


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
200mg35004 weeks
1g55004 weeks


Synonyms(R)-GSK3685032
CAS No.2170140-50-6
Purity>98%
FormulaC22H24N6OS
Mol Weight420.531
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 60 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Adams, Nicholas David, et al. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727A1.

[2]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017.

CoACoA of R-GSK3685032

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