Quarfloxin

Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.


Cat. No.: EX-A8371	Purity: >98%

	Chemical structure of Quarfloxin

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	499	in_stock
50mg	705	in_stock
100mg	979	in_stock
250mg	2236	in_stock
500mg	3626	in_stock
1g	5852	in_stock

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Synonyms	Itarnafloxin
Synonyms 2	CX 3543
CAS No.	865311-47-3
Purity	>98%
Formula	C35H33FN6O3
Mol Weight	604.6733
Color	light yellow to yellow
State	solid powder
Solubility	DMSO : 5 mg/mL (8.27 mM; Need ultrasonic; Dissolution under acidic conditions (HCl adjust to pH ?3; hygroscopic DMSO has a significant impact on product solubility, please use newly opened DMSO)
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hald ØH, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.
CoA	CoA of Quarfloxin

Smiles:	O=C1C2=C3N(C=C1C(NCC[C@@H]4CCCN4C)=O)C5=CC6=CC=CC=C6C=C5OC3=C(N7CC(C8=NC=CN=C8)CC7)C(F)=C2


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