QR-6401

QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].


Cat. No.: EX-A15000	Purity: >98%

	Chemical structure of QR-6401

For research only, Do not use for Human!

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CAS No.	2845096-18-4
Purity	>98%
Formula	C19H23N5O3
Mol Weight	369.4176
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yu Y, et al. Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. ACS Med Chem Lett. 2023 Feb 8;14(3):297-304.
CoA	CoA of QR-6401

Smiles:	O=C(N[C@H](C1)C[C@@H]1OC2)O[C@@H](C3)CC[C@@H]3C4=CC(NC5=NC2=CC=C5)=NN4


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