PZL-A

PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with AC50 s of 160 and 20 nM for A467T and G848S. PZL-A activates mtDNA synthesis in cells, enhancing biogenesis of the oxidative phosphorylation machinery and cellular respiration. PZL-A is promising for relieving POLG disease and other severe conditions linked to depletion of mtDNA .


Cat. No.: EX-A15669	Purity: >98%

	Chemical structure of PZL-A

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	772	in-stock
250mg	1150	in-stock
500mg	1595	in-stock
1g	2375	in-stock
3g	get quote	in-stock
5g	get quote	in-stock

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CAS No.	3068830-89-4
Purity	>98%
Formula	C19H17ClN4O2
Mol Weight	368.817
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Valenzuela S, et al. Small molecules restore mutant mitochondrial DNA polymerase activity. Nature. 2025 Jun; 642(8067):501-507.
CoA	CoA of PZL-A

Smiles:	ClC1=CC=CC2=C1OCC[C@@H]2NC(NC3=NN(C4=CC=CC=C4)C=C3)=O


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