Product Information:

Pyclen

Pyclen is an inhibitor of cell death induced by oxidative stress and an inhibitor of AB1-40 aggregation induced by Cu2+ ion. It can both prevent and disrupt Cu(2+) induced AB(1-40) aggregation.


Cat. No.: EX-A7743	Purity: >98%

	Chemical structure of Pyclen

For research only, Do not use for Human!

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CAS No.	78668-34-5
Purity	>98%
Formula	C11H18N4
Mol Weight	206.2874
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Le Fur, Mariane et al. “Pyclen Tri-n-butylphosphonate Ester as Potential Chelator for Targeted Radiotherapy: From Yttrium(III) Complexation to (90)Y Radiolabeling.” Inorganic chemistry vol. 55,16 (2016): 8003-12. [2]. Lincoln, Kimberly M et al. “A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.” Chemical communications (Cambridge, England) vol. 49,26 (2013): 2712-4. [3]. Lincoln, Kimberly M et al. “An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation.” ACS chemical neuroscience vol. 3,11 (2012): 919-27. [4]. Lincoln, Kimberly M et al. “Structural, spectral, and electrochemical properties of nickel(II), copper(II), and zinc(II) complexes containing 12-membered pyridine- and pyridol-based tetra-aza macrocycles.” Inorganic chemistry vol. 53,3 (2014): 1406-16.
CoA	CoA of Pyclen

Smiles:	C1(CNCCNCCNC2)=CC=CC2=N1


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