PU-H54

PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy . PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


Cat. No.: EX-A8519	Purity: >98%

	Chemical structure of PU-H54

For research only, Do not use for Human!

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CAS No.	1454619-13-6
Purity	>98%
Formula	C18H19N5S
Mol Weight	337.442
Color	White to off-white
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pallav D Patel, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov;9(11):677-84.
CoA	CoA of PU-H54

Smiles:	NC1=C2N=C(SC3=CC=C(C)C=C3C)N=C2N(CCCC#C)C=N1


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