PTD-DBM

PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing.


Cat. No.: EX-A13483	Purity: >95%

	Chemical structure of PTD-DBM

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	195	in-stock
25mg	395	in-stock
50mg	595	in-stock
100mg	895	in-stock
250mg	1325	in-stock
1g	2900	in-stock

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Synonyms	peptide PTD-DBM
Synonyms 2	PTD-DBM peptide
CAS No.	1609454-11-6
Purity	>95%
Formula	C124H225N61O28S2
Mol Weight	3082.635
Color	White to off-white
State	Solid
Solubility	H2O : ? 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder 80°C, 2 years , -20°C, 1 year, Sealed storage, away from moisture; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ryu YC, et al. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD₂. Cells. 2023;12(4):555. Published 2023 Feb 9. [2]. Kim E, et al. Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair. Exp Mol Med. 2023;55(8):1770-1782. [3]. Lee SH, et al. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. J Exp Med. 2015;212(7):1061-1080.
CoA	CoA of PTD-DBM

Smiles:	[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CS)=O)CCCCN)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC


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