PT2977

PT2977 (MK-6482, Belzutifan) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC).


Cat. No.: EX-A4441	Purity: >99%

	Chemical structure of PT2977

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	300	In-stock
250mg	565	In-stock
500mg	795	In-stock
1g	1072	In-stock
5g	3450	In-stock
10g	5920	In-stock

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Synonyms	MK-6482
Synonyms 2	Belzutifan
CAS No.	1672668-24-4
Purity	>99%
Formula	C17H12F3NO4S
Mol Weight	383.342
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xu R, et al. 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62(15):6876-6893.
CoA	CoA of PT2977

Smiles:	N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2[C@@H](F)[C@@H](F)[C@H]3O)=C1


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