PT262

PT-262 is a potent ROCK inhibitor with an IC50 value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity.


Cat. No.: EX-A12326	Purity: >98%

	Chemical structure of PT262

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	446	in_stock
250mg	864	in_stock
500mg	1384	in_stock
1g	2246	in_stock
2g	3558	in_stock
3g	4337	in_stock

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CAS No.	86811-36-1
Purity	>98%
Formula	C14H13ClN2O2
Mol Weight	276.718
Color	Brown to reddish brown
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light ; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tzu-Sheng Hsu, et al. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway. Cancer Chemother Pharmacol. 2008 Oct;62(5):799-808. [2]. Chih-Chien Tsai, et al. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration. Biochem Pharmacol. 2011 Apr 1;81(7):856-65.
CoA	CoA of PT262

Smiles:	O=C1C(Cl)=C(C(=O)C2=CC=CN=C12)N3CCCCC3


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