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Product Information:

PT2385

PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.

Cat. No.: EX-A2855    Purity: >98%
Chemical
Chemical structure of PT2385


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg500In-stock
250mg800In-stock
500mg1350In-stock
1g1950In-stock
5g5765In-stock
10g8785In-stock


SynonymsPT-2385
CAS No.1672665-49-4
Purity>98%
FormulaC17H12F3NO4S
Mol Weight383.342
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Eli Wallace, Ph.D. PT2385: HIF-2α Antagonist for the Treatment of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016.

[2]. Xie C, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23(11):1298-1308.

[3]. Wallace EM, et al. A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res. 2016 Sep 15;76(18):5491-500.

CoACoA of PT2385
Smiles:CS(=O)(=O)C1=CC=C(OC2=CC(=CC(F)=C2)C#N)C2=C1[C@H](O)C(F)(F)C2

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