PSN 375963 hydrochloride

PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA).


Cat. No.: EX-A8656A	Purity: >98%

	Chemical structure of PSN 375963 hydrochloride

For research only, Do not use for Human!

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CAS No.	1781834-82-9
Purity	>98%
Formula	C17H24ClN3O
Mol Weight	321.845

Reference:	[1].Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. [2].Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065.
CoA	CoA of PSN 375963 hydrochloride

Smiles:	CCCCC1CCC(C2=NC(C3=CC=NC=C3)=NO2)CC1.[H]Cl


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