PSI-7409

PSI-7409 is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.


Cat. No.: EX-A10647	Purity: >98%

	Chemical structure of PSI-7409

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	1100	In-stock
50mg	get quote	In-stock
100mg	get quote	In-stock

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CAS No.	1015073-42-3
Purity	>98%
Formula	C10H16FN2O14P3
Mol Weight	500.1587
Color	white to off-white
State	solid
Solubility	Soluble in H2O
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, sealed storage, away from moisture, 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. [2]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
CoA	CoA of PSI-7409

Smiles:	O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O


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