PSI-352938

PSI-352938 (PSI-938) is a HCV NS5B inhibitor potentially for the treatment of HCV infection. PSI-352938 exhibits a novel mechanism of resistance requiring multiple mutations within replicon RNA.


Cat. No.: EX-A5251	Purity: >98%

	Chemical structure of PSI-352938

For research only, Do not use for Human!

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Synonyms	PSI-938
Synonyms 2	GS-0938
CAS No.	1231747-17-3
Purity	>98%
Formula	C16H23FN5O6P
Mol Weight	431.3559
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lam AM, et al. Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA. J Virol. 2011 Dec;85(23):12334-42. [2]. Lam AM, et al. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine. Antimicrob Agents Chemother. 2011 Jun;55(6):2566-75. [3]. Guedj J, et al. Analysis of hepatitis C viral kinetics during administration of two nucleotide analogues: sofosbuvir (GS-7977) and GS-0938. Antivir Ther. 2014;19(2):211-20. doi: 10.3851/IMP2733.
CoA	CoA of PSI-352938

Smiles:	O=P1(OC(C)C)OC[C@]2([H])[C@@]([C@@](C)(F)[C@H](N3C(N=C(N)N=C4OCC)=C4N=C3)O2)([H])O1


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