PROTAC TEAD degrader-1

PROTAC TEAD degrader-1 (Compound 27) is a PROTAC degrader for transcriptional enhanced associate domain (TEAD). PROTAC TEAD degrader-1 selectively degrades the Flag TEAD2 in a ubiquitin proteasome-dependent manner, with a DC50 of 54.1 nM in 293T cells, inhibits proliferation of NF2-deficient NCI-H226 with an IC50 of 0.21 μM, and regulates expressions of yes associated protein (YAP) target genes.


Cat. No.: EX-A12657	Purity: >98%

	Chemical structure of PROTAC TEAD degrader-1

For research only, Do not use for Human!

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CAS No.	3061498-57-2
Purity	>98%
Formula	C44H41F3N6O7
Mol Weight	822.8275
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, protect from light, stored under nitrogen, 1 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li H, et al., Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS Med Chem Lett. 2024 Apr 22;15(5):631-639.
CoA	CoA of PROTAC TEAD degrader-1

Smiles:	O=C(N[C@H](C1=NC(NCCOCCOCCNC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=CC=C1)C)C5=CC=C6C(C7=CC=C(C(F)(F)F)C=C7)=CC=CC6=C5


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