PROTAC STING degrader-3

PROTAC STING degrader-3 is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI).


Cat. No.: EX-A16964	Purity: >98%

	Chemical structure of PROTAC STING degrader-3

For research only, Do not use for Human!

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CAS No.	3109967-69-0
Purity	>98%
Formula	C37H36N8O10
Mol Weight	752.7293
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ma R, et al. Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury. Eur J Med Chem. 2025;290:117539.
CoA	CoA of PROTAC STING degrader-3

Smiles:	O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(NC(/C=C/C(N3CCN(CC4CN(C5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)CC3)=O)=O)C=C2


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