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Product Information:

PROTAC STING Degrader-1

PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity.

Cat. No.: EX-A10226    Purity: >98%
Chemical
Chemical structure of PROTAC STING Degrader-1


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg950
500mg1750
1g2850
2gget quote
5gget quote


CAS No.2762552-74-7
Purity>98%
FormulaC34H33N7O10
Mol Weight699.6667
Colorlight yellow to yellow
Statesolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years, protect from light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611.

[2]. Rongxiang Ma, et al., Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury, European Journal of Medicinal Chemistry, Volume 290, 2025, 117539, ISSN 0223-5234.

[3]. Shuai Xu, et al., PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis, International Immunopharmacology, Volume 141, 2024, 112990, ISSN 1567-5769.

CoACoA of PROTAC STING Degrader-1
Smiles:O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)/C=C/C(NC4=CC=C(NC(C5=CC=C([N+]([O-])=O)O5)=O)C=C4)=O

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