PROTAC SOS1 degrader-5

PROTAC SOS1 degrader-5 is a potent SOS1 PROTAC degrader with a DC50 value of 13 nM. PROTAC SOS1 degrader-5 induces CRBN-dependent ubiquitination and degradation of SOS1 protein, inhibits the proliferation of KRAS G12C-mutated cancer cells, and suppresses tumor growth in xenograft models. PROTAC SOS1 degrader-5 can be used in studies related to KRAS G12C-mutated non-small cell lung cancer .


Cat. No.: EX-A9151	Purity: >98%

	Chemical structure of PROTAC SOS1 degrader-5

For research only, Do not use for Human!

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CAS No.	2836273-61-9
Purity	>98%
Formula	C45H51F3N8O7
Mol Weight	872.931
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pang X, et al. Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo. J Med Chem. 2024 Jan 25;67(2):1563-1579.
CoA	CoA of PROTAC SOS1 degrader-5


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