PROTAC SMARCA2/4-degrader-7

SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment.


Cat. No.: EX-A13347	Purity: >98%

	Chemical structure of PROTAC SMARCA2/4-degrader-7

For research only, Do not use for Human!

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CAS No.	2568277-89-2
Purity	>98%
Formula	C51H61N11O5S
Mol Weight	940.166
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
CoA	CoA of PROTAC SMARCA2/4-degrader-7

Smiles:	O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC([C@@H]2CC[C@@H](C3=CN=C(N4C5CN(C6=C(N)N=NC(C7=C(C=CC=C7)O)=C6)CC4CC5)N=C3)CC2)=O)=O)NC8(C9=CC=C(C%10=C(N=CS%10)C)C=C9)CC8


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