PROTAC SMARCA2/4-degrader-32

PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment.


Cat. No.: EX-A13393	Purity: >98%

	Chemical structure of PROTAC SMARCA2/4-degrader-32

For research only, Do not use for Human!

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CAS No.	2568273-79-8
Purity	>98%
Formula	C54H69N13O5S
Mol Weight	1012.275
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
CoA	CoA of PROTAC SMARCA2/4-degrader-32

Smiles:	NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@@H](N7CCN(CC7)CC(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@H](C8)O)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O)CC6)C=N5)C(CC4)C3


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