PROTAC PLK1 Degrader-3

PROTAC PLK1 Degrader-3 (Compound DD-1) is a PLK1 PROTAC degrader based on the N-deglycosylation pathway, with a Kd value of 2.2 μM. The cell penetration ability of PROTAC PLK1 Degrader-3 is limited and a higher concentration is required to achieve significant degradation effects. PROTAC PLK1 Degrader-3 can be used for research on non-small cell lung cancer .


Cat. No.: EX-A17202	Purity: >98%

	Chemical structure of PROTAC PLK1 Degrader-3

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	3074520-74-1
Purity	>98%
Formula	C102H196N57O23P
Mol Weight	2619.9895
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gunasekaran P, et al. Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer. J Med Chem. 2024 Mar 14;67(5):3307-3320.
CoA	CoA of PROTAC PLK1 Degrader-3

Smiles:	O=P(O)(O)O[C@H](C)[C@@H](C(N)=O)NC([C@H](CO)NC([C@H](CC1=CN=CN1)NC([C@H](CC(C)C)NC([C@H]2N(CCC2)C(CCCCCNC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC


		Search