PROTAC K-Ras Degrader-5

PROTAC K-Ras Degrader-5 is a cereblon-based K-Ras PROTAC degrader with a DC50 of <100 nM for KRAS G12D. PROTAC K-Ras Degrader-5 recruits KRAS G12D to the cereblon E3 ubiquitin ligase complex for ubiquitination and subsequent proteasomal degradation. PROTAC K-Ras Degrader-5 suppresses pERK levels downstream of KRAS G12D degradation in cancer cells. PROTAC K-Ras Degrader-5 reduces proliferation of cancer cells. PROTAC K-Ras Degrader-5 induces caspase 3/7 activity and cPARP, markers of apoptosis, in pancreatic cancer spheroids and tumors. PROTAC K-Ras Degrader-5 can be used for the research of pancreatic cancer and colorectal cancer .


Cat. No.: EX-A16817	Purity: >98%

	Chemical structure of PROTAC K-Ras Degrader-5

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	get quote

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CAS No.	3052745-16-8
Purity	>98%
Formula	C57H63F3N10O5
Mol Weight	1025.1693
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Jesus Raul Medina. Cereblon-based kras degrading protacs and uses related thereto. US20240287101A1.
CoA	CoA of PROTAC K-Ras Degrader-5

Smiles:	O=C1C2=CC=C(C(F)=C2CN1C3C(=O)NC(=O)CC3)N4CCC(CN5CCC(CC5)CC6CCN(CCOC7=NC8=C(F)C(=NC=C8C(=N7)N9CC%10NC(C9)CC%10)C=%11C=C(O)C=C%12C=CC(F)=C(C#C)C%12%11)CC6)CC4


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