PROTAC_ERRα

PROTAC_ERRα is a potent and selective ERRα PROTAC degrader (DC50: ~100 nM in MCF-7 cells). PROTAC_ERRα recruits the VHL E3 ubiquitin ligase to ERRα, inducing ERRα ubiquitination and proteasomal degradation in a VHL-dependent manner. PROTAC_ERRα can be used in breast cancer-related research.


Cat. No.: EX-A13865	Purity: >98%

	Chemical structure of PROTAC_ERRα

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	798	In-stock
10mg	1400	In-stock
25mg	2100	In-stock

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CAS No.	1801547-15-8
Purity	>98%
Formula	C46H47F3N6O9S2
Mol Weight	949.025
Color	White to off-white
State	Solid
Solubility	DMSO : 125 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years, 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bondeson DP, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nature chemical biology. 2015 Aug;11(8):611-7. [2]. Gu S, et al. PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery. Bioessays. 2018 Apr;40(4):e1700247. [3]. Coleman K G, et al. Proteolysis-targeting chimeras: harnessing the ubiquitin-proteasome system to induce degradation of specific target proteins[J]. Annual Review of Cancer Biology, 2018, 2: 41-58.
CoA	CoA of PROTAC_ERRα

Smiles:	O=C(/C(SC1=O)=C/C2=CC(OC)=C(C=C2)OC3=C(C=C(C=C3)C#N)C(F)(F)F)N1CCOCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O


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