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Product Information:

PROTAC ER Degrader-3

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

Cat. No.: EX-A8743    Purity: >98%
Chemical
Chemical structure of PROTAC ER Degrader-3


For research only, Do not use for Human!

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CAS No.2158322-29-1
Purity>98%
FormulaC71H77N7O12
Mol Weight1220.4108
 
 
Reference:  

[1].Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.

CoACoA of PROTAC ER Degrader-3
Smiles:OC1=CC=C(/C(C2=CC=C(OCCN(C)C(COCCOCCNC(C3=CC=C(C(N4[C@@H](C)[C@H](NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)C(N(CC5=C(OC)C=CC6=C5C=CC=C6)C7=C4C=C(C#N)C=C7)=O)=O)C=C3)=O)=O)C=C2)=C(CC)/C8=CC=CC=C8)C=C1

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