PROTAC EGFR degrader 16

PROTAC EGFR degrader 16 (Compound 98) a selective EGFR PROTAC degrader with DC50 values of < 50 nM in NCI-H1975 (EGFR L858R-T970M), NCI-H3225 (EGFR L858R) and NCI-H1976 + CS (EGFR L858R-T970M-L797S). PROTAC EGFR degrader 16 can be used for the study of EGFR-driven cancerssuch as non-small cell lung cancer.


Cat. No.: EX-A16017	Purity: >98%

	Chemical structure of PROTAC EGFR degrader 16

For research only, Do not use for Human!

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1g	get quote	inquire

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CAS No.	2654821-07-3
Purity	>98%
Formula	C48H48F2N10O6S
Mol Weight	931.02
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Christopher G, et al. EGFR DEGRADERS TO TREAT CANCER METASTASIS TO THE BRAIN OR CNS CROSS-REFERENCE TO RELATED APPLICATIONS. WO2022251539.
CoA	CoA of PROTAC EGFR degrader 16

Smiles:	O=C(NC1=NC=CS1)C(C2=C(CCC3)N3C=N2)N(CC4=C5C=C(C6=CC=C(N(C7)CC87CN(C(CC9(O)CCN(C%10=CC=C(N[C@H](CC%11)C(NC%11=O)=O)C=C%10F)CC9)=O)C8)C=C6)C=C4F)C5=O


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