PROTAC EED degrader-1

PROTAC EED degrader-1 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit.


Cat. No.: EX-A11472	Purity: >98%

	Chemical structure of PROTAC EED degrader-1

For research only, Do not use for Human!

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CAS No.	2639882-72-5
Purity	>98%
Formula	C55H60FN11O8S
Mol Weight	1054.197
Color	white to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, protect from light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
CoA	CoA of PROTAC EED degrader-1

Smiles:	N(CC1=C2C(OCC2)=CC=C1F)C=3N4C(C(=CN3)C5=C(C)N=C(CCC(NCCOC6=CC=C(OCC(N[C@H](C(=O)N7[C@H](C(NCC8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)[C@@](C)(C)C)=O)C=C6)=O)C=C5)=NN=C4


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