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Product Information:

PROTAC CDK6 ligand 1

Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.: EX-A13832    Purity: >98%
Chemical
Chemical structure of PROTAC CDK6 ligand 1


For research only, Do not use for Human!

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SynonymsPalbociclib-propargyl
CAS No.2366269-23-8
Purity>98%
FormulaC27H31N7O2
Mol Weight485.5807
ColorLight yellow to yellow
StateSolid
SolubilityDMSO : 3.33 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, stored under nitrogen; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.

CoACoA of PROTAC CDK6 ligand 1
Smiles:O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCN(CC#C)CC4)C=C3)N=C2N1C5CCCC5

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