PROTAC BRD4 Degrader-49

BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer .


Cat. No.: EX-A17357	Purity: >98%

	Chemical structure of PROTAC BRD4 Degrader-49

For research only, Do not use for Human!

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CAS No.	3115940-40-1
Purity	>98%
Formula	C53H67N9O6S2
Mol Weight	990.286

Reference:	[1].Ding Ke, et al. Annular BRD4 protein degradation agent and application thereof. CN120965801A. 2025-11-18.
CoA	CoA of PROTAC BRD4 Degrader-49

Smiles:	CC1=C(SC2=C1C(C3=CC=C(C=C3)OCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@]([H])(C(N[C@@H](CCCCCCN5)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C4)=O)=O)=N[C@]([H])(C8=NN=C(N28)C)CC5=O)C


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