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Product Information:

PROTAC BRD3/BRD4-L degrader-2

PROTAC BRD3/BRD4-L degrader-2 is a PROTAC molecule and can selectively degrade cellular BRD3 and BRD4-L with Ki values of 16.91 and 2.8 nM, respectively. PROTAC BRD3/BRD4-L degrader-2 also has robust antitumor activity in mouse xenograft models. PROTAC BRD3/BRD4-L degrader-2 can be used for the research of cancer .

Cat. No.: EX-A8714    Purity: >98%
Chemical
Chemical structure of PROTAC BRD3/BRD4-L degrader-2


For research only, Do not use for Human!

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Purity>98%
FormulaC43H44ClN7O3
Mol Weight742.308
 
 
Reference:  

[1]. Yan Z, et al. Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines. Eur J Med Chem. 2023;254:115381.

CoACoA of PROTAC BRD3/BRD4-L degrader-2
Smiles:CC1=NN=C2CCC(C3=C(N12)C=CC(C4=CC=C(C=C4)CN(C)CCCCC5=C6CN(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=C3)NC8=CC=C(C=C8)Cl

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