background


Product Information:

PROTAC BET degrader-2

PROTAC BET degrader-2 is a PROTAC connected by ligands for Cereblon and BET with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

Cat. No.: EX-A11410    Purity: >98%
Chemical
Chemical structure of PROTAC BET degrader-2


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1gget quoteInquire


SynonymsPROTACBETdegrader-2
CAS No.2093388-33-9
Purity>98%
FormulaC41H42N10O6
Mol Weight770.8356
ColorLight yellow to yellow
Statesolid
SolubilityDMSO : 50 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, stored under nitrogen; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

CoACoA of PROTAC BET degrader-2
Smiles:O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NCCCC7=CC=CC8=C7CN(C(CC9)C(NC9=O)=O)C8=O

KEYWORDS: buy PROTAC BET degrader-2 | PROTAC BET degrader-2 supplier | purchase | cost | manufacturer | order | distributor | buy 2093388-33-9 | 2093388-33-9 supplier