background


Product Information:

PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

Cat. No.: EX-A8728    Purity: >98%
Chemical
Chemical structure of PROTAC Bcl2 degrader-1


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mgget quoteInquire
1gget quoteInquire
2gget quoteInquire
3gget quoteInquire
5gget quoteInquire
10gget quoteInquire


SynonymsPROTAC Bcl2 degrader-1
CAS No.2378801-85-3
Purity>98%
FormulaC45H45BrN6O10S
Mol Weight941.842
ColorLight yellow to yellow
Statesolid powder
SolubilityDMSO: 25 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃, sealed storage, away from moisture and light
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.

CoACoA of PROTAC Bcl2 degrader-1
Smiles:O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O

KEYWORDS: buy PROTAC Bcl2 degrader-1 | PROTAC Bcl2 degrader-1 supplier | purchase | cost | manufacturer | order | distributor | buy 2378801-85-3 | 2378801-85-3 supplier