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Product Information:

PROTAC α-synuclein degrader 3

PROTAC α-synuclein degrader 3 (Compound 5) is a selective α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 can promote the ubiquitination and degradation of α-synuclein. PROTAC α-synuclein degrader 3 can be used for Parkinson's disease research.

Cat. No.: EX-A11337    Purity: >98%
Chemical
Chemical structure of PROTAC α-synuclein degrader 3


For research only, Do not use for Human!

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CAS No.2412273-77-7
Purity>98%
FormulaC51H68N6O11S2
Mol Weight1005.249
ColorWhite to light yellow
Statesolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Andrew PC, et, al. Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases. WO2020041331A1.

CoACoA of PROTAC α-synuclein degrader 3
Smiles:O(CCOCCOCCOCCOCCOCCOCC(N[C@H](C(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1)[C@@](C)(C)C)=O)C=4C=C5C(N=C(S5)C6=CC=C(NC)C=C6)=CC4

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