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Product Information:

Primordazine B

Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of selectively destroying Primordial Germ Cells (PGCs). Primordazine B inhibits a process called Poly(A)-tail Independent Non-canonical Translation (PAINT) without inhibition of polyadenylate tail dependent typical translation (PAT). Primordazine B can be used to study translational control of cells in specific physiological or pathological states, such as gene expression regulation during cell dormancy, viral infection, or stress conditions .

Cat. No.: EX-A9543    Purity: >98%
Chemical
Chemical structure of Primordazine B


For research only, Do not use for Human!

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CAS No.339337-07-4
Purity>98%
FormulaC18H17N5O2S
Mol Weight367.425
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Youngnam N Jin, et al. Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells[J]. Nature chemical biology, 2018, 14(9): 844-852.

CoACoA of Primordazine B
Smiles:O=C(NCC=1OC=CC1)CSC=2N=NC3=C(N2)N(C4=CC=CC=C34)CC

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