Prexasertib Mesylate Hydrate

Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib Mesylate Hydrate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity .


Cat. No.: EX-A758C	Purity: >98%

	Chemical structure of Prexasertib Mesylate Hydrate

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	648	In-stock
250mg	1098	In-stock
500mg	1618	In-stock
1g	2348	In-stock

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CAS No.	1234015-57-6
Purity	>98%
Formula	C19H25N7O6S
Mol Weight	479.51

Reference:	[1].King C, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015 Sep;14(9):2004-13. [2].Yin Y, et al. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017 Mar 1;7(3):473-483.
CoA	CoA of Prexasertib Mesylate Hydrate

Smiles:	N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O.O


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