PQA-18

PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM). PQA-18 has immunosuppressing effects. PQA-18 suppresses IL2, IL4, IL6, and TNFα. PQA-18 inhibits the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens as well as alleviates dermatitis in mice.


Cat. No.: EX-A11609	Purity: >98%

	Chemical structure of PQA-18

For research only, Do not use for Human!

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CAS No.	1604678-82-1
Purity	>98%
Formula	C25H31NO4
Mol Weight	409.5179
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 20 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65.
CoA	CoA of PQA-18

Smiles:	O=C(OCC=C(C)C)C=1N=C2C(OCC=C(C)C)=CC=CC2=C(OCC=C(C)C)C1


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