PPA24

PPA24 is a PP2A activator with a KD of 8.465 μM for PP2ACα. PPA24 induces cancer cell death via apoptosis. PP2ACα induces ROS generation and decreases the level of c-Myc expression. PPA24 can be used to study colorectal cancer (CRC), Folinic acid, 5-Fluorouracil, and Oxaliplatin (FOLFOX)-resistant CRC, and melanoma cancer.


Cat. No.: EX-A13394	Purity: >98%

	Chemical structure of PPA24

For research only, Do not use for Human!

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CAS No.	3035032-77-7
Purity	>98%
Formula	C22H27BrClN5S
Mol Weight	508.905
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Johnson H, et al. Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer. J Med Chem. 2024 Oct 24;67(20):18070-18089. [2]. Hannah Johnson, et al.Sharma; Abstract 1655: Discovery of a novel PP2A activator as a potential therapeutic for FOLFOX resistant colon cancer. Cancer Res 1 April 2023; 83 (7_Supplement): 1655. [3]. Hannah Johnson, et al. Abstract 7273: Small molecule activation of PP2A in the treatment of melanoma. Cancer Res 15 March 2024; 84 (6_Supplement): 7273.
CoA	CoA of PPA24

Smiles:	[Br-].ClC1=CC=C2SC=3C=CC=CC3N(C2=C1)CCCC[N+]45CN6CN(CN(C6)C4)C5


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