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Pomalidomide-C9-NH2 hydrochloride

Thalidomide-NH-C9-NH2 hydrochloride is the Thalidomide -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

Cat. No.: EX-A7900M    Purity: >97%
Chemical
Chemical structure of Pomalidomide-C9-NH2 hydrochloride


For research only, Do not use for Human!

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Synonyms1H-Isoindole-1,3(2H)-dione, 4-[(9-aminononyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
CAS No.2305936-77-8
Purity>97%
FormulaC22H31ClN4O4
Mol Weight450.959
ColorLight yellow to yellow
Statesolid powder
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1].Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]

CoACoA of Pomalidomide-C9-NH2 hydrochloride

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