Polθ/PARP-IN-1

Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity .


Cat. No.: EX-A16426	Purity: >98%

	Chemical structure of Polθ/PARP-IN-1

For research only, Do not use for Human!

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CAS No.	3056709-95-3
Purity	>98%
Formula	C38H33ClFN7O5S
Mol Weight	754.229
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Ma L, et al. Discovery and Proof of Concept of Potent Dual Polθ/PARP Inhibitors for Efficient Treatment of Homologous Recombination-Deficient Tumors. J Med Chem. 2024 Feb 20.
CoA	CoA of Polθ/PARP-IN-1

Smiles:	O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCC(COC5=NN=C(S5)NC(=O)C6=CN=C(C=C6C=7C=C(Cl)C=CC7OC)C)CC4


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