background


Product Information:

PLX5622

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an IC50=0.016 μM, Ki=5.9 nM.

Cat. No.: EX-A3165    Purity: >98%
Chemical
Chemical structure of PLX5622


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg585In-stock
1g800In-stock
2g1465In-stock
5g2950In-stock
10g4380In-stock


CAS No.1303420-67-8
Purity>98%
FormulaC21H19F2N5O
Mol Weight395.4053
Colorwhite ot light yellow
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758.

[2]. Lee S, et al. Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain. Mol Pain. 2018 Jan-Dec;14:1744806918764979.

[3]. Liu Y, et al. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019;318:32-41.

[4]. Badimon A, et al. Negative feedback control of neuronal activity by microglia. Nature. 2020;586(7829):417-423.

[5]. Andrew J. Riquier, et al. Astrocytic response to neural injury is larger during development than in adulthood and is not predicated upon the presence of microglia, Brain, Behavior, & Immunity-Health, Volume 1, 2020, 100010, ISSN 2666-3546.

[6]. Spangenberg EE, et al. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain. 2016;139(Pt 4):1265-1281.

CoACoA of PLX5622
Smiles:COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2

KEYWORDS: buy PLX5622 | PLX5622 supplier | purchase | cost | manufacturer | order | distributor | buy 1303420-67-8 | 1303420-67-8 supplier