PLX-4545

PLX-4545 is an orally available, cereblon-based IKZF2 (zinc finger transcription factor Helios) molecular glue degrader that reprograms immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses.


Cat. No.: EX-A9763	Purity: >98%

	Chemical structure of PLX-4545

For research only, Do not use for Human!

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CAS No.	2892065-45-9
Purity	>98%
Formula	C28H31N3O4
Mol Weight	473.5634
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Huang Y, et al. PLX-4545, a selective IKZF2 degrader, reprograms suppressive Tregs leading to tumor growth inhibition and combination benefit with immune checkpoint therapy[J]. Cancer Research, 2025, 85(8_Supplement_1): 6380-6380. [2]. Chen Z, et al. Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy. Nat Commun. 2025 May 1;16(1):4095. [3]. Zhang X, et al. Discovery of a Novel Series of iso-Indolinone-Based Glutarimides as Highly Efficacious and Selective IKZF2 Molecular Glue Degraders. J Med Chem. 2025 Sep 11;68(17):18230-18257.
CoA	CoA of PLX-4545

Smiles:	O=C1CC[C@@H](C(N1)=O)N2CC3=C(C2=O)C=CC(O[C@H]4CCCC[C@@H]4N5CC(C5)C6=CC=CC=C6)=C3


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