background


Product Information:

PLK1-IN-10

PLK1-IN-10 (Compound 4Bb) is an orally active PLK1 PBD (polo-box domain) inhibitor. PLK1-IN-10 blocks the interaction of PLK1 with the cell division regulator protein 1 (PRC1) and decreases the protein expression of the CDK1-Cyclin B1 complex. PLK1-IN-10 reacts with glutathione (GSH) to increase cellular oxidative stress, ultimately leading to cell death.

Cat. No.: EX-A13914    Purity: >98%
Chemical
Chemical structure of PLK1-IN-10


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mgget quoteInquire
1gget quote
5gget quote


CAS No.2991469-21-5
Purity>98%
FormulaC23H22FN3O4S
Mol Weight455.502
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Li P, Li Y, et al. Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells. Eur J Med Chem. 2024 May 5;271:116416.

CoACoA of PLK1-IN-10
Smiles:O=C1C2=CC=CC=3C(=CC=C(C(=O)N1CCN(C)C)C23)S(=O)(=O)NCC4=CC=C(F)C=C4

KEYWORDS: buy PLK1-IN-10 | PLK1-IN-10 supplier | purchase | cost | manufacturer | order | distributor | buy 2991469-21-5 | 2991469-21-5 supplier