Pitstop 2

Pitstop 2 is an inhibitor of the interaction between the clathrin terminal domain and amphiphysin (IC50 = 12 μM). It inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM, respectively). Pitstop 2 inhibits HIV-1 entry and infectivity in HeLa reporter cell lines. It also inhibits clathrin-independent endocytosis of CD44, CD98, and CD147 in HeLa cells.


Cat. No.: EX-A7548	Purity: >98%

	Chemical structure of Pitstop 2

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	585	In-stock
200mg	785	In-stock
500mg	1185	In-stock
1g	1785	In-stock

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CAS No.	1332879-52-3
Purity	>98%
Formula	C20H13BrN2O3S2
Mol Weight	473.363

Reference:	[1]. von Kleist, Lisa et al. “Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.” Cell vol. 146,3 (2011): 471-84. [1]. Dutta, Dipannita et al. “Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis.” PloS one vol. 7,9 (2012): e45799.
CoA	CoA of Pitstop 2


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