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Product Information:

PI3Kδ-IN-23

PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC50 of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research .

Cat. No.: EX-A15993    Purity: >98%
Chemical
Chemical structure of PI3Kδ-IN-23


For research only, Do not use for Human!

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CAS No.3051828-81-7
Purity>98%
FormulaC30H30N6O5
Mol Weight554.5964
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bo Yuan, et al. Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation. J Med Chem. 2024 Nov 28;67(22):20076-20099.

CoACoA of PI3Kδ-IN-23
Smiles:N(C=1C2=C(C=CC(=N2)C=3C=C(C(OC4=CC=CC=C4)=O)C(OC)=NC3)N=CN1)[C@@H]5CN(C(=O)C6CCOCC6)CC5

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